Yes! Shoes regularly...

• Encourage the muscles in the feet and lower legs to be weak.
• Provide an incubator-like environment that can encourage the growth of fungus and athlete's foot.
• Squeeze the toes together bringing them out of proper alignment.
• Negatively alter our body's alignment and posture.
• Encourage a host of health problems from corns to joint pain.
• Cut off important sensory feedback from the ground to the thousands of nerve endings in our soles.

Even primal footwear, a better option when shoes are prudent, can cause some of these issues. Barefoot, whenever possible, really is best.